What Is The Endocannabinoid System?

What Is The Endocannabinoid System?

Endocannabinoid System is a natural system in the body of animals, mammals in particular – including humans; that use bodily produced cannabis compounds to keep the body healthy. It covers psychological, emotional and physical health that promotes homeostasis. The CBD trend has everyone rethinking on how they view cannabis as a natural drug alternative to address different ailments.


Brief History of the Endocannabinoid System

The Endocannabinoid System in mammals was first discovered only a few decades ago. It all started in 1964 by an Israeli scientist, Raphael Mechoulam when he was able to pinpoint and isolate THC compound and later on CBD. By isolating these compounds, the discovery of ECS wasn’t far behind.  It can be found in almost all living things with vertebrae.  Without hemp or marijuana, a biological system with great importance will not be discovered. The plant became the basis to look at the human body in a new light, on how it functions, cure and keep itself healthy.


  • 1988 – Allyn Howlett and William Devane found the first cannabinoid receptor in the brain of a rat. It turned out that there are many of these receptors than any other neurotransmitter in the brain.
  • In specific studies on THC and its effect – synthetic THC was formulated and is now an FDA approved, a drug that prevents and treat acute nausea and wasting syndrome, to map out the Cannabinoid receptors in the brain. And these receptors are mostly located in mental and physiological processes such as memory, high cognition, appetite, motor coordination and area affecting moods.
  • So the conclusion is if there are receptors for cannabinoid in the brain, then the compounds can’t only be sourced out, instead, they are naturally produced by the body.
  • 1993 was the year the second receptor was discovered in the immune and nervous system. The second receptor or CB2 can be found throughout the stomach or gut, spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, and the reproductive organs.


The newly discovered system in the body of mammals and other animals is all due to the study of one plant, marijuana. It’s been used for centuries for its medicinal properties as well as for indigenous rituals. Its psychoactive effect has been deemed dangerous and addictive. But the good news, other compounds such as CBD or cannabidiol can now be extracted and isolated from the THC. And they can be used for our health and well being. Thanks to the work of scientists and researchers who saw the potential of hemp/marijuana.


5 Things You Need To Know About The EndoCannabinoid System (ECS)


  1. As discussed earlier, ECS is fairly a new discovery because of two reasons; it exists in two parts that are undetected as they interact with other systems and varying concentrations within the body; and it is made up of different microcellular proteins, receptors, and enzymes. Compared to the skeletal or nervous system that is apparent and has a bigger scale, ECS moves within sub-cellular dynamics.
  2. ECS actually clarifies the efficacy of cannabinoids in hemp in curing and preventing diseases as well as in promoting well being. Before it has been prohibited largely because of its psychoactive ingredient, hemp has been used in ancient medicine such as in Ayurveda to cure depression, anger and pain management. It was also long been a cure for epilepsy, seizures, and nausea. Because of its medicinal content, science has probed deeper into the qualities of the plant and found the connection with the body’s cannabinoid orientation and production.
  3. The Endocannabinoid System receptors, also known as CB1 and CB2 act as keys to attaining holistic well being also known as homeostasis. Inherently, the body moves towards health and balance. This means it exerts efforts to keep everything running smoothly and in working condition. This is called homeostasis. CB1 receptors are found mostly in the brain as they regulate moods and help in pain management. CB2 receptors are found in the immune system, organs and nervous system managing healing of wounds and inflammation.
  4. The discovery of the ECS led scientist to prove that there’s a link to a deficiency in the system that can be a primary cause of certain diseases. When the endocannabinoid system is damaged or inherently dysfunctional, certain chronic conditions become present such as migraines, fibromyalgia, and IBS. This is known as Clinical Endocannabinoid Deficiency Syndrome.  This is connected to sensitivity to pain and inflammation. Augmenting this deficiency with the intake of organic cannabinoid from plants will put the ECS on the right track, relieving symptoms and promote health and well-being.
  5. Because ECS plays a big role in keeping the body healthy and deficiency proved to affect the function of the body – including mental and emotional well-being. Neurological-degenerative disorders such as anxiety, depression, Alzheimer’s and Parkinson’s, chronic inflammatory disorders including rheumatoid arthritis and cancer express fluctuations in EC levels. It is now considered that by tapping into the ECS through the intake of CBD and THC organic products can restore balance and promote health.


Thanks to the tireless research on the potential of hemp or marijuana in curing diseases from cancer, degenerative and chronic conditions, ECS was discovered. And it clarifies the long forgotten route of using plant-based medicine to cure and prevent diseases as well as for maintaining health and overall well-being.


Last Word On ECS

We’ve looked far and beyond our natural resources to look for cures and to promote health. Only to go back to our roots that’s long been abandoned by science, and then find that we are carriers of cannabinoids. That they are an intrinsic part of our bodies’ functioning efficiently. We can naturally increase our endocannabinoid levels through exercise and diet. Exercise increases the production of anandamide – mood-boosting endocannabinoid. Increasing our intake of essential fatty acids including omega 3 from fish and seeds such as flax or hemp boosts endocannabinoid signaling in the brain. CBD oil and other infused products such as edibles, inhalants, salves, and lotions can promote health and well-being by supplementing our natural production of CBD.

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